Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p016 | Ovary | WCRB2014

Rho-GTPase effector ROCK regulates mouse oocyte maturation and embryo development

Duan Xing , Wang Zhen-Bo , Cui Xiang-Shun , Kim Nam-Hyung , Sun Shao-Chen

Introduction: ROCK (Rho kinase) is a Rho-GTPase effector that is involved in various cellular functions, such as stress fiber formation, cell migration, tumor cell invasion, and cell motility. In this study, we investigated possible roles for ROCK in mouse oocyte meiosis and embryo development.Materials and methods: Time lapse microscopy, immunofluorescence staining, western blotting, RNAi and inhibitor treatment were adopted to analyze the roles of ROCK...